Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants

Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants

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Summary: The universal importance of epigenetic regulation has become explicit over the last decade.There is now a detailed understanding of the molecular signatures and chromatin-modifying enzymes determining epigenetic regulation.For example, the trimethylation of lysine 27 at 9002nc histone H3 by Polycomb complexes is a hallmark of silenced gene expression conserved across animal and plant kingdoms.

The repressive activity of Polycomb complexes is balanced by the histone demethylase activity of Jumonji C-domain proteins.There has been a lot of research on Polycomb functions and H3K27 methylation; however, until recently, little was known about the role of histone H3K27 demethylases.Here, we review the role of Jumonji C-domain proteins from the plant development perspective.

We will recall the history of histone lysine demethylation diamond painting strand en zee and explore the recent advances on the H3K27 demethylases in plant biology.Conserved and novel genomic functions of these epigenetic regulators will be discussed.